ABSTRACT
The problem of viral pneumoenteritis of young farm animals is relevant for agriculture of the Republic of Belarus. Today, the most effective method of preventing viral pneumoenteritis of calves is vaccination of pregnant cows. In case of mixed infections, the most effective means of preventing such diseases are polyvalent vaccines. But biological preparations should have not only high preventive effectiveness, but also not affect the quality of the final product. The author of the article studied the effect of a polyvalent inactivated culture vaccine against infectious rhinotracheitis, viral diarrhea, parainfluenza-3, respiratory syncytial, rotavirus and coronavirus infection of cattle left-pointing-double-angle BolsheVak right-pointing-double-angle on the state of metabolism of pregnant cows. For this purpose, 3 groups of pregnant cows of the Belarusian black-and-white Holstein breed were formed in the conditions of the Agricultural Republican subsidiary of the Ulishitsy Agro enterprise of the Gorodok district on the principle of pairs of analogues with10 animals in each group for 1.5-2 months before calving. The cows of the first experimental group were immunized with the vaccine against viral pneumoenteritis "Bolshevak" with the adjuvant ISA-15 intramuscularly into the croup area in compliance with the rules of asepsis and antiseptics in the volume of 5.0 cm3. Cows of the second experimental group were immunized with the vaccine against viral pneumoenteritis "Bolshevak" with the adjuvant ISA-25 - in the volume of 3.0 cm3. The cows of the control group were injected with isotonic sodium chloride solution according to a similar scheme. The animals were immunized twice with an interval of 21 days. The sampling was carried out before the start of the studies, on the 14th, 21st days after the first vaccination and on the 45th day after the revaccination. The clinical condition of the animals was monitored for 70 days. As a result of the research, it was found that the studied vaccine against viral pneumoenteritis does not have a negative effect on the general condition of the animal, does not cause allergic reactions, abortions, does not inhibit the synthesis of the studied biochemical parameters of the serum.